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Loading contentWeightlifting in orbit. Devices such as the ISS's Advanced Resistive Exercise Device let crews load their bones and muscles against a resistance in place of gravity — the single most important countermeasure against bone and muscle loss.
The physiological effects this countermeasure targets.
Facts on this topic will be cited from these primary and reference sources.
Mission data, planetary science, space telescopes, and public-domain imagery.
Most NASA-produced imagery is in the public domain; individual items are checked for usage terms before publication.